At the core of a digital model (DM) is a physical/mathematical model that captures the behavior of the real system across temporal and spatial scales. One of the key roles of DMs is enabling “what if” scenario testing of hypothetical simulations to understand the implications at any point throughout the life cycle of the process, to monitor the process, to calibrate parameters to match the actual process and to quantify the uncertainties. In this talk, we will present various (faster than) real-time Scientific Deep Learning (SciDL) approaches for forward, inverse, and UQ problems. Both theoretical and numerical results for various problems including transport, heat, Burgers, (transonic and supersonic) Euler, and Navier-Stokes equations will be presented.